She is known for her feminist video, computer and internet art and has been active since the early 1980s.

[1][2][3] Along with collaborator Jim Gimzewski she is thought to have created one of the first interactive artworks related to nanotechnology (sometimes called nanoart)[4][5][6] and defines her art practice as experimental research.

In 2000, she completed her Ph.D. at CAiiA (The Centre for Advanced Studies in Interactive Arts) at the University of Wales with a thesis entitled "Networked Public Spaces: An Investigation into Virtual Embodiment" in 2000.

[12] Artweek reviewer Claudine Isé writes, “Vesna has created a number of Web-based works that examine the dichotomy between concepts of “virtual’ and ‘concrete.’ Her on-line projects include an upcoming electronic conference about the cultural production of death as well as a popular site called Bodies INCorporated, which gives visitors an opportunity to design their own ‘cyber bodies’ from a selection of organic and synthetic textures, such as water, lava, chocolate, rubber or plastic.”[13] In Christopher Hanson's review of her book Database aesthetics: Art in the age of information overflow, he says that Vesna provides an engaging collection of essays about changing aesthetics in interactive art and its relationship to the database.

[14] Formerly married to Bogdan Maglich, Vesna has two children by that marriage, which ended in divorce.