She debuted in director T. S. Nagabharana's film Nagamandala, based on a folk tale, opposite Prakash Raj.

In 2006, it was reported that Vijayalakshmi attempted suicide by overdosing on sleeping pills after being harassed by an assistant director who wanted to marry her.

[citation needed] The decision came at the end of a difficult year for her in which her father also had died, but she survived and recovered thereafter.

[1] Vijayalakshmi filed a complaint in February 2020 accusing Seeman of cheating her after being in a relationship with her and claimed that he had not married her despite making promises.

[11][12] After being allegedly harassed by Seeman and his supporters, she attempted suicide again in July 2020 by overdosing on blood pressure tablets and was admitted to hospital.