Villa María is a small village (caserío) in the San José Department of southern Uruguay.

It is located on km.71 of Route 3, 4 kilometres (2.5 mi) north of its junction with Route 1 and 3.2 kilometres (2.0 mi) northeast of Rafael Perazza (by secondary road).

Route 3 connects it to the department capital, San José de Mayo, 19 kilometres (12 mi) to the north, as well as to the capitals or main cities of other departments.

In 2011 Villa María had a population of 620.

This article about a place in San José Department is a stub.