It is situated in via San Bartolomeo degli Armeni 25, in the quarter of Castelletto, in an area that, at the time when the villa was built, was still outside of the city walls.

[1][2] While the villa was being constructed, Tobia Pallavicino also commissioned his city palace in the Strada Nuova (Italian for "New Street", now via Garibaldi), known today as Palazzo Carrega-Cataldi.

[6] Charles Dickens is one of the notable guests who stayed at the villa and described in his Pictures from Italy the views over the city and the Acquasola gardens which one could enjoy from the park.

The southern facade is sumptuously decorated, with geometrical compositions and a decorative scheme of Ionic and Corinthian lesene[1] The internal stuccoes and the hexagonal bathroom (a bizarre fashion of the time, documented in several Genoese villas, but preserved only in Villa delle Peschiere) were realized by Marcello Sparzo, a member of the school of Giovanni Battista Castello.

[1] The garden, whose original condition is known today thanks to the drawings of Martin-Pierre Gauthier,[8] has been greatly reduced in size in the 19th century when Via Peschiera was built.