Lloyd was born in Beresford, South Dakota, and after graduating from Yankton College in 1940 started his career with a number of local radio stations around the Midwest.
Lloyd then began a more than 20-year radio run partnered with Hall of Fame shortstop Lou Boudreau.
Vince Lloyd was also the first baseball announcer to interview a current US president on TV, when he spoke to John F. Kennedy during the White Sox TV pre-game show for the traditional Washington, D.C. season opener, at Griffith Stadium on April 10, 1961.
In the 1966–67 season, Lloyd teamed with Boudreau on Bulls' broadcasts for WGN Radio.
[1] Lloyd died of stomach cancer on July 3, 2003, in Green Valley, Arizona.