[9] AllMusic characterizes the band's musical style as "utiliz[ing] a bone-crushing rhythm section, apocalyptic samples, and a unique triple-guitar assault to deliver their signature blend of hardcore punk, noise, death metal and doom metal.

"[5] The site's review of Wormwood elaborates on the band's sound as "an inelegant and unstoppable juggernaut fueled by memories of the unchecked aggression unleashed on the world by the likes of Sepultura and Pantera.

"[13] The Acacia Strain's influences include Candiria, Integrity, Dismember, Rush, Iron Maiden, Crowbar, Meshuggah, Hatebreed, Slayer, Arch Enemy, and Overcast.

[14][12][15] Written by lead vocalist Vincent Bennett, the band's lyrics generally center around misanthropy[16] and nihilism.

[17] Bennett employs misogynistic and sexually deviant imagery in his lyrics, but usually only as metaphors to help get his points across while keeping the songs' overall meanings open for interpretation.