Vincenzo was born at Monterubbiano, near Fermo in the region of March to a father who served as a magistrate, but also had an affinity for painting.
He appears to have apprenticed in his father's workshop, being influenced by Carlo Crivelli (as shown by canvasses at Ortezzano, from c. 1510).
[2] After leaving Rome, he traveled to Rieti where he painted a Final Judgement fresco in the chapter hall of the Dominican Monastery.
[4] In the 1520s he was influenced by the Venetian painting school, which he had known from Antonio Solario, then at Fermo, and Lorenzo Lotto, who was working at Recanati.
From this period are the Madonna with Four Saints (church at Moresco) and the altarpieces of San Ginesio (1533–1538), and Sant'Agostino, Ascoli Piceno.