[5] San Ginesio is located at 680 m above sea level[6] and is the 5th highest and 12th largest municipality in the province of Macerata.

[9] The village, also nicknamed "the village of 100 churches",[10] also stands on a panoramic site that allows the view of the municipalities of Civitanova Marche, Gualdo, Ripe San Ginesio and Monte San Martino, of the hamlets of Passo San Ginesio, Pian di Pieca and Santa Croce (belonging to the municipality itself), of the hamlet of Sassotetto (municipality of Sarnano) and the view of the Adriatic Sea and the wind turbines of Serrapetrona.

To avoid problems of water distribution, the country is equipped with a large reservoir, which in case of shortages compensates for the need.

The village is divided into four districts (Porta Ascarana, Offuna, Picena, Alvaneto) that compete every year in the traditional palio contest.

[11] It is probable that the place previously called "Avia" or "Oppidum esculanum" changed in the toponym San Ginesio after the passage of the Franks of Charlemagne.