He was signed by the Minnesota Vikings of the National Football League (NFL) as an undrafted free agent in 2009.
Perretta is a 2004 graduate of La Costa Canyon High School in Encinitas, CA where he was a two-time First-team All-Avocado League selection.
Perretta is best known for throwing the touchdown pass in overtime to Derek Schouman in the 2007 Fiesta Bowl to help Boise State beat Oklahoma 43–42 in what many consider to be the best college football game ever played.
In 2008, as a senior, Perretta caught 36 passes for 578 yards and 2 touchdowns and helped Boise State post an undefeated 12–0 regular season mark.
In 2005, he was part of Boise State's wide receiver rotation and played in all 13 games, catching 12 passes for 169 yards.