Born at his family's estate of Florica, in Ștefănești, Argeș County, Vintilă Brătianu started his studies at Saint Sava High School in Bucharest.

After the war, he served as Finance Minister (19 January 1922–9 March 1926) in the Liberal government led by his brother, Ion.

[2] After his brother died on 24 November 1927, he assumed the post of Prime Minister of Romania until he was forced to resign a year later to allow the new National Peasants' Party government of Iuliu Maniu to take office.

In November 1927 he also assumed the presidency of the National Liberal Party; he remained in that position until the end of his life.

On 22 December 1930 Brătianu was at his estate in Mihăești, Vâlcea, when he had a stroke of apoplexy which paralyzed his left side; he died that evening at the hospital in nearby Râmnicu Vâlcea.