Born in Rome in 1785, she was the daughter of an architect, Giulio, and Maddalena Belli.

After marrying Giustiniani, she found herself in financial difficulties and therefore thought of dedicating herself to singing professionally.

While in Paris, she trained with Girolamo Crescentini for quite some time to improve her vocal qualities.

The political events of those years forced her to leave the country to England where she debuted at Theatre Royal Haymarket on 11 January 1817 in Cimarosa's opera, Penelope.

Her noted performances includes Mozart's Don Giovanni, La clemenza di Tito, Le nozze di Figaro and Rossini's La gazza ladra, Otello, La donna del lago, Bianca e Falliero.