[1] After beginning a career in standup comedy, Das moved to Hindi cinema starring in films like Badmaash Company (2010), Delhi Belly (2011), and Go Goa Gone (2013) in supporting roles.

[6][8] There he obtained a bachelor's degree from Knox College, Galesburg, Illinois in Economics and Theatre with a concentration in performance.

[6] After graduating from Knox, Das was accepted into the Harvard University's and Moscow Arts Theatre for their joint Stanislavsky Program.

He contrasted India's rich vs. poor, criticised politicians and democratic backsliding, and noted divisions over Bollywood films and cricket teams.

The performance received a standing ovation,[13] but Indian politicians filed seven police complaints against Das, including for insulting India on foreign soil.

[14] In November 2022, Mumbai police issued an FIR against Vir Das and two other persons and online streaming platform Netflix on charges of copyright rules violation,[15] following a complaint by noted theatre producer Ashvin Gidwani of AGP World that Das re-used material from his previous show in his Netflix special.

[16] He began his career with a gig at one of the premier hotels in New Delhi with a performance titled "Walking on Broken Das".

Das was cast as the comic relief in The Curse of King Tut's Tomb, a Hallmark mini-series filmed in India.

[21] In 2019, Das released his travel-cum-comedy show Jestination Unknown where he explores how Indians see humour along with a couple of other stand-up comedians and celebrities.

[22] He starred opposite Preity Zinta in a Fresh Off the Boat episode titled "The Magic Motor Inn".