The Virgin and Child with Saint Anne, also known as Sant'Anna Metterza, is a painting of c. 1424–1425 by the Italian Renaissance painter Masaccio, probably in collaboration with Masolino da Panicale.

[1] The Virgin and Child, with its powerful volume and solid possession of space by means of an assured perspectival structure, is one of the earliest works credited to Masaccio.

The figure of Saint Anne is much worn and hence to be judged with difficulty, but her hand, which seems to explore the depth of the picture-space, may well be an invention of Masaccio.

Masaccio's work shows the influence of Donatello in its soft, rounded forms and realistic texture.

The figure of Christ is that of a young child, a realistic presence, rather than a gothic cherub.