Her artwork is known for its surrealist qualities, material experimentation, and thematic blending of science, mysticism, metaphysics, and 21st century feminist autobiography.

[4] Montgomery is an ecofeminist artist whose work utilizes symbolic imagery like circles, holes, and spheres to facilitate unexpected and multi-layered insights about the natural world, gender, technology, the human subconscious, and visual language .

[8] For over a decade, Virginia L. Montgomery has worked as a graphic facilitator, mapping concepts in diverse settings ranging from health care conferences to the launch of an app at South by Southwest in Austin.

[7] Montgomery states in an interview with She/Folk magazine, "[Through my art] I can survey relationships between bodies, hierarchies between objects, genders, sound or forms, and thus allow forth a message to emerge from these intersecting realms of cognitive awareness and sensorial participation.

[10] In the exhibition catalog for Crash Test, Curator Nicolas Bourriaud writes, "...Montgomery's works display images atomized by technology: their aim is no longer to represent the world, but to find the points through which it manifests itself and operates, the source from which it draws its morphological power, in other words its capacity to generate forms and to produce effects.

Inspired by Dr. Donna Haraway's ecofeminist writings, this live-action film collages together imagery of real Luna moths amidst an ethereal dreamworld.

Butterfly Birth Bed was featured inside the Film and Video Gallery of the Blanton Museum, Austin, Texas for the exhibition Day Jobs curated by Veronica Roberts.

[9][8] The Sky Loop exhibition is a video art installation using a psychoanalytic perspective to explore the artist's firsthand experience of Hurricane Harvey in 2017.

[27] Montgomery was interviewed by NPR correspondent Catherine Lu about the Sky Loop video exhibition on KUHT Houston Public Media, 88.7FM radio.

[30] In an interview with Times Square Arts, \Montgomery said of the Honey Moon project, "We live in an age that often feels more unreal than real, in which things seem to move faster than we can perceive them.

"[30] Midnight Moment is the world's largest, longest-running digital art exhibition, synchronized on electronic billboards throughout Times Square with an estimated annual viewership of 2.5 million.

The Pony Hotel artwork was part of a video art exhibition series shown at New York City's New Museum in 2019.

Curatorial Assistant Kate Weiner wrote that the artworks, including Pony Hotel, "interrogate the relationship between physical and psychic structures.

Water Witching was commissioned by New York's Center for Curatorial Studies at Bard College for the exhibition, "An unbound knot in the wind" curated by Alison Karasyk.

Writer Wendy Vogel for Art in America magazine noted that the sculpture overturns the masculine bravado of the tales of King Arthur and Oedipus.

Montgomery created a large free-standing public sculpture outside the Yale Physics Department's building entitled, Portal (2017).

Its shape is inspired by the medieval divination tool known as the Y-rod that was traditionally employed as an alternative means for discovering natural resources such as water, oil, or gold.