Known as College Drive, the state highway runs 2.20 miles (3.54 km) from U.S. Route 17 (US 17) north to the entrance of Tidewater Community College, where the highway continues as SR 367, within the independent city of Suffolk.

SR 135 begins at an intersection with US 17 (Bridge Road) to the west of the village of Churchland.

The intersection is very close to the tripoint of the boundaries of the independent cities of Suffolk, Chesapeake, and Portsmouth.

SR 135 heads north as a four-lane divided highway and immediately has a partial diamond interchange that allows access to SR 164 (Western Freeway) to and from the east.

The state highway reduces to two lanes for the final stretch to its northern terminus at the entrance of the Tidewater Community College's Regional Workforce Development Center and Truck Driver Training Site, which fronts Hampton Roads at Pig Point.