SR 208 begins at an intersection with US 250 (Three Notch Road) in the hamlet of Ferncliff along the southern edge of Louisa County.

SR 22 reaches its eastern terminus at the highways' intersection with US 522, which heads south along the same roadway but with a different name, Mineral Avenue.

SR 208 continues through Spotsylvania County as Courthouse Road, which passes through Brokenburg and crosses the Ta River, one of four main tributaries of the Mattaponi River on its way to Post Oak, where the highway makes a sharp turn east at SR 606 (Post Oak Road).

The state highway continues northeast as Courthouse Road, which crosses the Ni River, the northernmost Mattaponi tributary, and Massaponax Creek and passes through the suburban area southwest of Fredericksburg.

SR 208 crosses over I-95 with no access before reaching its northern terminus at a four-leg intersection with US 1 (Jefferson Davis Highway) and US 1 Business (Lafayette Boulevard) at Four Mile Fork.

SR 208 Business crosses the Po River at Snells Bridge and enters Spotsylvania Courthouse.