SR 225 connects Interstate 264 (I-264) with US 58 in the Pembroke Manor area of the city and with US 13 near Naval Amphibious Base Little Creek and the Chesapeake Bay Bridge-Tunnel.

SR 225 begins at a four-leg intersection with South Boulevard, which parallels I-264 east from the intersection; Baxter Road, which heads southwest toward the Kempsville area of Virginia Beach; and Independence Boulevard, which continues southeast as an eight-lane divided highway toward the city offices in the Princess Anne section of the city.

The ramp from eastbound I-264 to Independence Boulevard splits, with one leg passing over Baxter Road to merge with the southbound direction south of SR 225's terminus.

The state highway passes between multiple densely populated suburban residential subdivisions on its way to the Little Creek area of Virginia Beach.

The state highway reaches its northern terminus at US 60 (Shore Drive) on the southern edge of Naval Amphibious Base Little Creek.