[1] She was chosen by Georges Goven to play in the Fed Cup first round when Tatiana Golovin had an injury and Marion Bartoli and Émilie Loit were suspended.

On 31 August 2006, Razzano upset eighth seed Martina Hingis in the second round of the US Open.

2 seed, she defeated first-time finalist, 34-year-old Israeli Tzipora Obziler, to claim the title and become the 2007 Guangzhou International Women's Open champion.

On 8 January, Razzano lost to Ana Ivanovic in the first round of the Sydney International in three sets.

In the third set, Razzano was ahead 5–2, only to see Ivanovic win the next five games, and eventually proceed to the semifinals.

After beating Evgeniya Rodina, she was forced to retire during her second-round match against 18th seed Kaia Kanepi due to a back injury.

Razzano reached the quarterfinals of Charleston as the 13th seed, but lost again to Wozniacki, again in straight sets.

Razzano was seeded 16th at the US Open, but suffered a surprise defeat in the first round to eventual semifinalist Yanina Wickmayer.

Razzano continued her disappointing end to the season in Tokyo as the 16th seed, losing to Iveta Benešová, in the first round.

Razzano was seeded 18th at the Australian Open, but suffered another surprise defeat in the first round to Ekaterina Makarova.

Razzano continued her season in Dubai where, as an unseeded player, she defeated Selima Sfar in the first round, before losing to world No.

Due to her not defending her points from reaching the final the previous year, Razzano saw a huge change in her ranking as it fell to world No.

Razzano next competed at Indian Wells where she defeated Kristina Barrois in the second round, before losing to 32nd seed Maria Kirilenko in the third.

At the US Open, she beat Klara Zakopalova and upset 13th seed Marion Bartoli, before losing to former No.

Razzano started off the year losing in the second qualifying round to Vania King at the Brisbane International.

Prior to the French Open's start, Razzano's fiancé and former coach, Stephane Vidal, died of a brain tumor.

She elected to play despite her loss, knowing that Vidal encouraged her to participate at Roland Garros.

5 seed Serena Williams her first-ever singles first-round defeat in a Grand Slam tournament.

At the time, Razzano was ranked 106 places lower than Williams, who was the favourite for the title entering the tournament.

[9] In May, Razzano reached the singles semifinals of the Internationaux de Strasbourg for the second consecutive year.