Virtua Cop 3 retains the same gameplay as its predecessor with players shooting onscreen enemies using a gun controller.

During the pharmacy mission, Rage and Smarty encounter a mysterious man known as "Gale", a ninja with unknown intentions.

Proceeding deeper inside the pharmacy research lab, Rage and Smarty encounter a man named "Glitter", who masterminded the invasion.

Rage and Smarty survive Gale and pursue the bank robbers, ultimately being pushed towards the subway where Brand is hiding.

Rage, Smarty, and Janet make a sneak attack through the sewers before ultimately catching up with the military base.

Enduring the heavily guarded area, the three make it inside the hangars where a crab-like mech provokes the three to a life-or-death duel.

Ultimately, they defeat Dino Fang and ECM's main facility self-destructs as the Virtua Cops narrowly escape from the explosion.

To be able to play this mission, the player must satisfy the following conditions: In early 1997 Electronic Gaming Monthly reported that "[Virtua] Cop 3 is in development but it won't make its debut until the September JAMMA show".