Founded in 1890 by the Franciscan Sisters of Perpetual Adoration, Viterbo is home to three colleges with nine schools offering 48 academic programs at the associate, bachelor's, master's, and doctoral levels.

[5] College courses were later introduced in 1923 as Viterbo began laying the foundation to evolve into a four-year degree-granting institution.

In 1940, Viterbo College held its first commencement exercises with certification from the State Department of Public Instruction.

[2] Viterbo's campus is on 21 acres of land in the Midtown district of La Crosse, Wisconsin, minutes from the city's downtown.

The Mathy Center is a collaboration between Viterbo and the local Boys and Girls Clubs of La Crosse—the first such effort in the country.

The remodel included upgrades to the security desk, flooring, computer area, television, and furniture.

[11] SMRT buses stop on 11th Street, providing regional bus service to Prairie du Chien, Viroqua, Tomah and other destinations.

Men's sports include baseball, basketball, bowling, cross country, golf, soccer, track & field (indoor and outdoor) and volleyball; women's sports include basketball, bowling, cross country, golf, soccer, softball, track & field (indoor and outdoor) and volleyball; and co-ed sports include competitive dance and eSports.