From 1968 to 1969 he worked at Azienda Nazionale Idrogenazione Combustibili (Eni group's society) in Milan; later he became the Istituto Mobiliare Italiano (IMI)'s evaluation expert in textile, clothing, iron and steel, and mechanical industries, until 1977.
His daughter, Chiara Gamberale – a well-known writer and anchor woman – (then only seventeen) drew on that event to write her first novel, Una vita sottile (Marsilio, 1999), turned into a fiction for the RAI.
He became vicepresident of 21 Investimenti SpA, an industrial participation company controlled by Benetton, Banca Intesa, Deutsche Bank and Assicurazioni Generali.
He was a promoter and Chairman of Amici della Speranza, a non-profit association supporting the haematology division of the San Giovanni Hospital in Rome, which was then merged to RomAil, an organisation where Gamberale has been a member of the Board until his resignation in February 2021.
In June 2015, he entered the share capital and was appointed Chairman of Iterchimica,[5] an Italian company which operates in over 70 countries, producing and distributing products for the enhancement of asphalt performance and the laying of road surfaces.