The highest peaks are located in the ridge of Komonec Mountains in the northeastern part of the territory.

The highest peaks of the Vizovice Highlands are: The territory has a relatively regular shape and stretches from southwest to northeast.

The region has an area of 1,399 square kilometres (540 sq mi) and an average elevation of 339 m (1,112 ft).

The most populated settlements located in whole or in large part in the territory are the city of Zlín and the towns of Uherský Brod, Veselí nad Moravou, Napajedla, Slavičín, Luhačovice, Vizovice, Bojkovice, Fryšták and Slušovice.

The Bílé Karpaty Protected Landscape Area extends into the Vizovice Highlands in the east.