Previously, he was the Presidential Plenipotentiary Envoy to the Ural Federal District from 2020 to 2024, Minister of Construction, Housing and Utilities from 2018 to 2020,[1] and Governor of Tyumen Oblast from 2005 to 2018.

On 27 June 1993, Yakushev started his career as a legal adviser of the Yamal-Nenets branch of the West Siberian Commercial Bank (Zapsibcombank).

[5] On 18 May 2018, he was appointed Minister of Construction, Housing and Utilities in Medvedev's second cabinet.

This happened the day after Prime Minister Mikhail Mishustin was also diagnosed with the coronavirus.

[6] In response to the 2022 Russian invasion of Ukraine, on 6 April 2022 the Office of Foreign Assets Control of the United States Department of the Treasury added Yakushev to its list of persons sanctioned pursuant to Executive Order 14024.