Voacamine, also known under the older names voacanginine and vocamine, is a naturally occurring dimeric indole alkaloid of the secologanin type, found in a number of plants, including Voacanga africana and Tabernaemontana divaricata.

It is approved for use as an antimalarial drug in several African countries.

[1] Voacamine exhibits cannabinoid CB1 receptor antagonistic activity.

[2] There is considerable confusion about the absolute stereochemical configuration of voacamine and the originally published absolute structure had to be later revised.

Voacamine can cause hypertension in high dose.