[5][6][7] The Wiskott–Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton.

Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3.

It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes.

[7] According to one study, mouse DAB1 regulates actin cytoskeleton through N-WASP.

[8] Diseases associated with WASL include Wiskottt-Aldrich Syndrome and Vaccinia.