1AWI, 1CF0, 1CJF, 1FIK, 1FIL, 1PFL, 2PAV, 2PBD, 3CHW, 4X1L, 4X1M, 4X25521618643ENSG00000108518ENSMUSG00000018293P07737P62962NM_005022NM_001375991NM_011072NP_005013NP_001362920NP_035202Profilin-1 is a protein that in humans is encoded by the PFN1 gene.

[5][6] The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family.

It is thought to regulate actin polymerization in response to extracellular signals.

[7] Mutations in this gene may be a rare cause of amyotrophic lateral sclerosis, also called Lou Gehrig's disease.

[8][9][10][11][12][13][14][15][16][17][18][19][20] Profilin-1 is a pseudouridine-binding protein and contributes to stability and translation efficiency of certain mRNAs.