[3] The WH2 motif (for Wiskott–Aldrich syndrome homology region 2) has been shown in WAS and Scar1/WASF1 (mammalian homologue) to interact via their WH2 motifs with actin.

The WH2 (WASP-Homology 2, or Wiskott–Aldrich homology 2) domain is an ~18 amino acids actin-binding motif.

This domain was first recognized as an essential element for the regulation of the cytoskeleton by the mammalian Wiskott–Aldrich syndrome protein (WASP) family.

WH2 proteins occur in eukaryotes from yeast to mammals, in insect viruses, and in some bacteria.

[4][5] Human genes encoding proteins containing the WH2 motif include: