Owned by Nexstar Media Group, the station has studios on TV Road in southwest Jackson, and its transmitter is located in Raymond, Mississippi.

WHLT (channel 22) in Hattiesburg operates as a semi-satellite of WJTV extending the CBS signal into the Pine Belt region of Mississippi.

Although WHLT maintains its own studios on US 49 in Hattiesburg, master control and some internal operations are based at WJTV's facilities.

Due to the presence of WHLT, this acquisition put Raycom in violation of Federal Communications Commission (FCC) duopoly rules in the Hattiesburg–Laurel market.

As a result, Raycom opted to keep the higher-rated WDAM and trade WJTV and WHLT (along with WSAV-TV in Savannah, Georgia, that also had to be divested by Raycom due to its ownership of that station's rival WTOC-TV) to Media General in exchange for WTVR-TV in Richmond, Virginia (which had to be divested by Media General due to FCC same-market cross-ownership restrictions).

The trade left Raycom without a station in the Jackson market until 2006 when it acquired WLBT as part of its purchase of The Liberty Corporation.

On October 1, 2013, WJTV returned programming from The CW to the Jackson market after a five-month absence due to former affiliate WRBJ-TV (channel 34)'s sale to the religious Trinity Broadcasting Network.

The 10 p.m. newscast is anchored by WJTV personalities Melanie Christopher, Byron Brown, and chief meteorologist Ken South, and is specially produced for the Hattiesburg market.