The two stations share studios at 4 Broadcast Place on the south bank of the St. Johns River in Jacksonville; WJXT's transmitter is located on Anders Boulevard in the city's Killarney Shores section.

The Washington Post Company sold WMBR-AM-FM in 1958, while it kept the television station, whose callsign it changed to the current WJXT.

In 1973, WJXT's FCC license renewal was challenged by supporters of President Richard Nixon following the Watergate coverage of his administration by The Washington Post, whose parent company owned the station.

[4] In 2001, WJXT was awarded the local broadcast rights to Jacksonville Jaguars preseason football games, replacing WTLV as the official station for the NFL franchise (WTLV had carried preseason games and Jaguars-related programs starting with the team's 1995 inaugural season); the deal also included carriage of the team's coaches show and other Jaguars-related television programs.

[11] WJXT retained rights to Jaguars preseason games for one additional year following the switch, despite the fact that the AFC regular season and playoff football games had moved to WTEV due to national broadcast rights held by CBS and a contract stipulation that reserved the team the right to move local broadcasts of preseason games and other Jaguars programs to another station if WJXT changed its network affiliation.

Because of the ownership structure of the Jacksonville market's Big Four network affiliates, WJXT is the only television station in the market whose news department operates independently of the other local stations (WTLV and WJXX have jointly produced their newscasts since WTLV owner Gannett's 2000 purchase of WJXX and the resulting consolidation of their news departments, and WAWS transferred production duties of its news department to SSA partner WTEV following that station's 2002 affiliation switch to CBS).

Its evening news team of anchors Tom Wills and Deborah Gianoulis, chief meteorologist George Winterling and sports director Sam Kouvaris were together for 22 years from 1981 until Gianoulis' retirement in 2003 – one of the longest-running anchor teams in the nation at the time.

[19] The upgrade saw the introduction of new on-air graphics (opens were designed in-house at Detroit sister station WDIV-TV, while the graphics were designed at Miami sister station WPLG) and news music (commissioning an updated version of the "WJXT News Theme", a customized package that was originally used from 1992 to 1997, and was composed specifically for the station by Gari Media Group), as well as the upgrade to robotic and computer-operated cameras for studio segments within its newscasts, the automation of its control room using the Miranda Vertigo system and Ignite technology.

[20] On May 21, 2012, Metro Jacksonville, a news and discussion blog on local urban issues, announced that it would enter into a content partnership with WJXT.

The WJXT analog signal had transmitted from that site for over two decades following a failure on the original transmitter tower at the station's 4 Broadcast Place studios.

Several monitors at WJXT's South Bank studios were reported by on-camera talent to have gone out upon the digital switchover.