Owned by WRNN-TV Associates, the station maintains a transmitter in the unincorporated community of Wye Mills in Talbot County, Maryland, 41 miles (66 km) southwest of Dover.

Outside of a morning rebroadcast of the Japanese network Fuji TV's News Catch program, the station's schedule on its main channel is made up of home shopping programming from Shop LC, which also airs on the main channel of all of WRNN's stations.

Because WMDE is a full-powered station covered by must-carry regulations, it is thus carried on every cable and satellite provider in the Washington market, with the exception of Cox Communications' systems in Fairfax County, Virginia.

Cox filed a complaint to the Federal Communications Commission seeking to avoid carriage and prevailed in 2015.

[3] WRNN-TV Associates agreed to acquire the station for $11.5 million on April 25, 2018;[4] the sale was completed on July 11, 2018.