WMEI was founded on February 28, 1990 by locally owned Arecibo Broadcasting Systems, managed by Hector Negroni Cartagena.
On December 28, 1994, WMEI launched WWKQ-LP (channel 26), a low-power TV station in Quebradillas owned by Signal Broadcasting.
WMEI, along with its satellite stations, went off the air for several months in early 2009 due to their shutting down analog signals in January 2009 in preparation for the nationwide digital transition.
WMEI became an affiliate once again in February 2013, this time with TeLe-Romántica, whose programming included telenovelas, movies, series and documentaries.
TeLe-Romántica resumed operations in August 2014 due to the station's website failure and moved its programming to WSJU-TV channel 31.2.
In November 2013, Power Television International acquired the non-license assets of WMEI and its satellite stations from Corporate Media Consultants Group for $18 million.
[citation needed] On April 1, 2016, WMEI changed its branding to reflect the station's digital channel number.
On December 8, 2016, WQQZ-CD returned to the air broadcasting the full Retro TV and Action Channel programming.
In April 2017, WMEI announced that it would shut down on August 31 following the Federal Communications Commission (FCC)'s incentive auction.
Due to the passage of Hurricane Irma across Puerto Rico, the license for WMEI was cancelled on September 12, 2017.