These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis.

[5] WNT10A is strongly expressed in the cell lines of promyelocytic leukemia and Burkitt's lymphoma.

In addition, it and another family member, the WNT6 gene, are strongly coexpressed in colorectal cancer cell lines.

The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway.

[10] This article incorporates text from the United States National Library of Medicine, which is in the public domain.