Paxson Communications purchased the station in 1995 and turned it into an all-infomercial format as part of the Infomall TV Network (inTV), though it also aired the daily greyhound racing recap program from Kenosha's Dairyland Greyhound Park for many years after WVTV (channel 18) stopped carrying that show in 1996, which met the station's local programming requirements.
[citation needed] The station became a charter affiliate of Pax TV (now Ion) when it launched on August 31, 1998, at which time it changed its call letters to WPXE-TV.
On September 24, 2020, it was announced that the Cincinnati-based E. W. Scripps Company, owner of NBC affiliate WTMJ-TV (channel 4), would purchase Ion Media for $2.65 billion, with financing from Berkshire Hathaway.
The station had a past joint sales agreement (JSA) with WTMJ-TV under Journal ownership that resulted from that station's affiliated network, NBC, having a stake in Paxson Communications/Pax TV; this resulted in the two stations sharing programming (such as Martha Stewart Living and repeats of preseason Green Bay Packers games produced for WTMJ, and live games during the 2004 Summer Olympics, which aired on WPXE), WPXE airing repeats of WTMJ's evening newscasts for several years, and WTMJ selling advertising time for WPXE.
WPXE airs the entire Ion schedule and since the repeal of the Main Studio Rule, it carries the network without any local content outside of an hourly on-screen station identification.