Owned by Inyo Broadcast Holdings, the station maintains offices on Exchange Street in Buffalo, and its transmitter is located in Cowlesville, New York.
[2] Until August 2019, WPXJ-TV's transmitter was based at Pavilion, approximately halfway between Western New York's two largest cities, Buffalo and Rochester; it was the only station to serve both markets with the same signal (WNYB still serves both markets, but relies on translators and cable carriage to do so), although what little local programming the station has carried has traditionally favored Buffalo, and Ion now maintains a separate Rochester affiliation on the fourth digital subchannel of WHEC-TV.
On September 24, 2020, the Cincinnati-based E. W. Scripps Company announced that it would purchase Ion Media for $2.65 billion, with financing from Berkshire Hathaway.
The buyer, revealed in an October 2020 FCC filing to be Inyo Broadcast Holdings, has promised to maintain the stations' Ion Television affiliations after the purchase.
This would have made it a sister station to ABC affiliate WKBW-TV (channel 7) if Scripps had decided to keep WPXJ-TV, but Buffalo has fewer than eight independently owned and operating full-power television stations, not enough to permit a duopoly in any case (even as both Nexstar Media Group and Sinclair Broadcast Group both hold longstanding duopolies in the same market).