Owned by Inyo Broadcast Holdings, the station maintains offices on Horizon Drive in Grand Rapids and a transmitter on South Norris Road in Orangeville Township.
WZPX first signed on the air on October 11, 1996, as WJUE, carrying infomercials for most of the day as part of Paxson Communications' inTV service, along with programming from the United Paramount Network (UPN) as a secondary affiliation.
When Paxson bought WBSX-TV in Ann Arbor (now WPXD-TV), WJUE was spun off to DP Media, a sister company because of Federal Communications Commission (FCC) ownership rules in effect at the time.
As UPN, WB and Pax TV all offered prime time programming on weekdays, WZPX had scheduling conflicts during its affiliations with the former two networks.
In part, because the station had the added draw of UPN and later WB programming, WZPX was at one point one of Pax TV's highest-rated affiliates.
Due to the closure of The WB on September 17, 2006, WZPX became solely an Ion owned-and-operated station (The CW and MyNetworkTV chose to affiliate with subchannels of WWMT and WXSP-CD, respectively, allowing full prime time carriage of their schedules).
With this purchase, Scripps divested 23 Ion-owned stations, allowing the merged company to fully comply with the FCC local and national ownership regulations.