The Wabash Bridge carries a single track railroad from St. Louis County to the city of St. Charles.

At 5:30pm on December 8, 1881,[1] the bridge failed again during a train crossing resulting in freight cars falling into the river.

An engineer, John Kirksby of Moberly, Missouri,[1] died along with thirty-one cattle contained in the freight cars.

[3] In June 2013, the Missouri River rose rapidly overnight causing a crane mounted to a barge to collide into the truss structure of the bridge.

In 2016, owner operator Norfolk Southern Corporation began installing a new tie deck across the bridge with a completion date of 2020.