Wake Up has earned praises from Hou Wen Yong, an anaesthesiologist and the author of renowned Taiwanese novel The Hospital.

When a patient died from a rare anaesthesia complication (malignant hyperthermia) during a medical operation led by the hospital's Chief Physician Chen Hsien Rong (Michael Huang), anaesthesiologist Dr. Hsiao Zheng Xun (Jag Huang) was pressured to take the blame and suspended from duty.

A troubled Hsiao then approaches psychiatrist Yang Wei Yu (Hsu Wei-ning) to help him with psychology treatments.

Facing pressure from the corrupted hospital system and his past trauma, would Hsiao fight for his conscience or would he give up and conform?

Tenacious in doing good and perceived as inflexible, also fears additional responsibility; where he mentioned that anaesthesiologists have no room for mistakes and that he does not want to become the Head of Anaesthesiology.

Due to prolonged work hours and mental stress, he suffers from insomnia and thus treasures his off time.

In the second episode, a patient died from a rare anaesthesia complication (Malignant Hyperthermia, MK) during a medical operation and Hsiao was blamed for the accident and suspended from duty due to his prolonged deprivation of sleep and alcoholism.

In the sixth episode, he was listed as a wanted criminal and helped in the life-saving of the bus accident at Min An Hospital.

In the fourth episode, it was revealed that her family from her mother side has a history of depression, hence motivating her to become a psychiatrist.

In the last episode, Yeh was reminded of the time when he received his junior, also a physician involved in the Li De Hospital embroilment, Lin Hong Ren's suicide note.

He sacrificed his students Yeh Jian De and Lin Hong Ren so that he is able to head abroad for advanced studies.

Assistant Chief Physician of Ren Xin Hospital, Wu Tzu-Chiang is the Chen Hsien Rong's junior.

The medical operation of Madam Zhang reunited her with former schoolmate Hsiao Zheng Xun, hence reminding them both of their traumatic past.

Lin Hong Ren was a student of Chen Hsien Rong, and has a similar attitude towards saving lives to Hsiao.

Suffering from the stress of public opinions and the inability to find a new job or get reinstated in duty, he committed suicide at the age of 27.