[4] Upon graduation from university, Wang was sent to the Asian section of the Ministry of Foreign Affairs by his father-in-law Qian Jiadong, where he began his career as a diplomat.

In June 2008, Wang succeeded Chen Yunlin as the director of Taiwan Affairs Office of the State Council of China.

[7] On 16 March 2013, during the first session of the 12th National People's Congress (NPC), Wang was appointed Minister of Foreign Affairs, succeeding Yang Jiechi.

[8] China's foreign policy under Xi Jinping's has been described as increasingly assertive, even to the point of being dubbed Wolf warrior diplomacy.

[12] On the evening of 15 April 2018, Wang was received by his Japanese counterpart Taro Kono, on the first such official visit of a foreign minister of China to Japan since November 2009.

[13] During a joint news conference in Ottawa on 1 June 2016, with Canadian Minister of Foreign Affairs Stéphane Dion, Wang responded to Canadian reporter Amanda Connolly of online news site iPolitics over a question she raised regarding human rights in China, saying "Your question is full of prejudice against China and arrogance ...

"[18] However, journalists from the British broadcaster BBC claim to have been followed by unmarked cars, chased out of restaurants and shops, and compelled to delete footage while trying to report from Xinjiang.

[24] On 22 February 2021, Wang urged the administration of US president Joe Biden to lift the sanctions on trade and people-to-people contact imposed by his predecessor, Donald Trump.

[35] Wang chose to have his Chargé d'affaires Dai Bing [zh] not present his peace plan at the 18th plenary meeting of the eleventh emergency special session of the United Nations General Assembly.

He decided to have Dai mention his peace plan only by passing reference at the UN Security Council Briefing on Ukraine the next day, 24 February 2023.

"[37] On 23 July 2024, the Ukrainian foreign minister Dmytro Kuleba visited China for talks ways to achieve a peaceful end to the war with Russia.

[38][39] On 3 July 2023, at the 2023 International Forum for Trilateral Cooperation in Qingdao, Wang made remarks during a speech towards the participating Japanese and South Korean audience where he called for Japan and South Korea to work together with China to "prosper together, revitalize East Asia, revitalize Asia and benefit the world" and said that "most Americans and Europeans can't tell China, Japan and South Korea apart" and that "no matter how blonde you dye your hair, how sharp you shape your nose, you can never become a European or American, you can never become a Westerner."

"[40][41] On 13 October 2023, during the Israel–Hamas war, Israel's Ministry of Foreign Affairs expressed "deep disappointment" over China's failure to condemn the Palestinian militant group Hamas.