It sits on the north bank of Ohio River, downstream of the F. B. Culley Generating Station.

[1] The Power Plant is primarily fueled by Illinois Basin coal, which is mined from the nearby region.

Warrick Plant discharges all of its waste heat (about twice its electrical output) into Ohio River.

In 2006, Warrick Plant was the third most-polluting major power station in the US in terms of sulphur dioxide gas emission rate: it discharged 32.69 pounds (14.83 kg) of SO2 for each MWh of electric power produced that year (92,919 tons of SO2 per year in total).

With the control systems fully operational and online in 2009, the plant saw more than a 95 percent reduction in sulfur dioxide emissions and other compounds.