Originating in the fields east of Regina near Vibank, Wascana Creek travels south-east for approximately 45 kilometres (28 mi) before turning back west at Tyvan.

The creek then travels in a north-westwardly direction following Highway 33 through Regina, where it was dammed by the Canadian Pacific Railway to create Wascana Lake.

[3] Below the lake, the creek leaves Regina and ends at the Qu'Appelle River about 1 mile west of Lumsden.

A 2011 study by Environment Canada found the creek to have high levels of pollution.

Several small tributaries feed the river, three of which are named: Brook stickleback and fathead minnow can be found in the Wascana Lake portion of the creek.