It travels north through Bingen as Oak Street and turns northwest to ascend a ridge and enter the adjacent settlement of White Salmon.

[3] SR 141 enters a rural area on the outskirts of White Salmon and descends towards a plateau, making a sharp turn west over a stream and north to follow Winebarger Road.

At BZ Corner, it intersects a local highway that travels northeast to Glenwood and the Conboy Lake National Wildlife Refuge.

[3] The highway travels north through the expanded White Salmon River Valley and reaches the town of Trout Lake near Mount Adams, where it turns west towards the Cascade Mountains, following Cave Creek.

[12] The state government funded several improvements to the road, including a steel truss bridge across the White Salmon River at Husum Falls that opened in 1940.

[21] Traffic congestion on SR 141 during peak months has risen due to an increase in the number of visitors to recreational facilities on the corridor, requiring lowered speed limits to prevent vehicle–pedestrian collisions.

[22] A shoulder rumble strip on the highway was removed and replaced with a fog stripe during a chip sealing project in 2014, causing local residents and recreational users to protest.