After merging with Rockville Road, Washington Street heads more directly east toward downtown Indianapolis.

Approaching downtown it passes the Indiana Medical History Museum on the former site of Central State Hospital for the Insane; it then passes the headquarters of the Indianapolis Public Transportation Corporation, which is in buildings that once housed the Duesenberg Automobile and Motors Company.

[2] Washington also runs under the Indianapolis Artsgarden, a suspended glass structure at the intersection with Illinois Street.

In the Irvington Historic District, an early suburb of Indianapolis, Washington crosses Pleasant Run Creek with its associated parkway and trail.

The street travels south of the Washington Square Mall as it approaches Cumberland, Indiana, where it terminates at Carroll Road.