It is located on the southward of canal Khlong Bangkok Noi, next to the Siriraj Piyamaharajkarun Hospital and Bangkok Noi railway station near the foot of Arun Ammarin bridge, considered as the temple that is nearest to Siriraj Hospital.

In the early Rattanakosin period, the King Phutthayotfa Chulalok (Rama I) gave the name to the Wat Amarinthraram (Śakra temple) which remains today.

The attraction of the temple is the principal Buddha statue of Luang Pho Bot Noi (หลวงพ่อโบสถ์น้อย), which is as the name says, located in the chapel behind the main hall.

The temple was heavily damaged by Allied bombings during World War II and the only building which was still standing was the chapel.

In the year 2010, the Buddha's footprint pavilion is preserved by the Fine Arts Department and Crown Property Bureau.