He played college football for the Michigan State Spartans, earning consensus All-American honors.

[5] Coming out of High School, Worthy was ranked the 53rd Best Defensive Tackle by Rivals.com, 78th by Scout.com, and 93rd by Scouts Inc.[5] He was also invited to play June 14 Big 33 Football Classic.

[5] Worthy received scholarship offers from Michigan State, Akron, Cincinnati, Marshall, Nebraska, and Ohio.

Worthy was redshirted for his freshman year but was still named the scout team defensive player of the week versus Eastern Michigan.

[5] Coming on to the scene in 2009, he started 11 of 13 games and ranked second on the team for tackles for loss and sacks.

Worthy became the first defensive tackle since Ronald Curl in 1971 to be named an All-American at Michigan State.

[11] They also stated that he had enough speed to "shoot through the gap"[12] Scouts also discussed his inconsistency and that his reputation was better than his actual production.

[12] It was also stated that he struggled in space and could not translate his weight enough to make tackles on the ball carrier.

The Detroit Lions cut Worthy from the team on September 5, 2015, at the 53 man roster deadline.