[2] Weberbauerocereus cuzcoensis grows like a tree with richly branched, sprawling, grey-green shoots with a diameter of 4 to 7 cm (1.6 to 2.8 in) and reaches heights of 3 to 4 meters with 10 to 14 ribs that are 6 to 11 mm (0.24 to 0.43 in) high and extremely blunt.

The areoles on the stem are oval to circular and covered with white wool and strong, yellow to brownish spines.

The somewhat radially symmetrical, unpleasantly scented flowers open at night.

[3] Weberbauerocereus cuzcoensis is distributed in the Peruvian regions of Apurímac and Ayacucho at altitudes of 1500 to 2100 meters.

The specific epithet cuzcoensis refers to the occurrence of the species near Cuzco.