[1] Weberbauerocereus madidiensis grows as a shrub with more or less upright, cylindrical shoots 10–15(–33) cm in diameter, that branch out from the base and 5–7 meters tall.

Areolas have (11)13 to 19 spines that are brown and yellowish spines in the apical part, slightly shiny, mature stems with thorns whitish below; ribs 16 to 24, 1–2.4 34.5–7.9 mm.

The strong flower tube is reddish and covered with dark hairs.

The spherical fruits are round, covered with scales and hairs, greenish-reddish to brown, white pulp with a diameter of 3 cm.

[2][3] Plants are found in the Department of La Paz in Bolivia, growing in successional forest between 730 and 1200 meters.