Served by lines 51, 53, and 54 of the Amsterdam Metro, it was constructed using caissons with a length and width of 40 metres (130 ft).

Weesperplein and other metro stations on the East Line were designed by two architects from the Government of Amsterdam: Ben Spängberg and Sier van Rhijn [nl].

[4] The latter, opened in 1980 and owned by a couple, was sold off in late 2023 to the restaurant located inside the Waterlooplein metro station.

[12] Since the second line was almost guaranteed to be built at the time, the decision was made to start work on the bottom platform in advance as building it afterwards would have been too complicated.

[14] This area only had the space to fit in an island platform, as columns supporting the entire station structure above limited the size of the tunnel.

The bureau released five reports by 1966 and laid out a final plan for a total of four metro lines in the city, which was presented to the public in the same year during a press conference by alderman Roel de Wit.

A month later, the council approved the plans based on the advice of the bureau and reserved 5 million Dutch guilder for the design of the eastern branches of the two East–West lines.

[21] The Dutch Government agreed to fund half of the project in February 1970 and compensate for eventual cost overruns related to workers wages.

Shortly after construction started, it became clear that the initial budget would be overrun, and the estimated cost had increased to over 800 million guilder by 1972.

[24] Most underground areas of the metro line were constructed by using caissons, which made pumping out groundwater unnecessary.

[26] While the construction near Weesperplein was not an issue, a tram stop with multiple amenities dating back to 1923 had to be destroyed for the metro.

[31] A train was first rolled into the underground tunnels by the GVB on 25 January 1977, and mayor Ivo Samkalden drove the metro under supervision.

[33] Before the public opening, journalists and members of the municipal council were given a ride from Amsterdam Amstel to Weesperplein.

[38] A lot of raw concrete was visible in the original brutalist architecture of the East Line stations.

[39] Most of the concrete in underground stations was later painted over with light coloured anti-graffiti coating in order to prevent vandalism.

[41][42] A high-speed tram caught fire at the Weesperplein station on 12 July 1999 due to a blocked disc brake.

Although the tram was carrying no passengers at the time, the smoke coming from the fire caused all levels of the station to be evacuated.

[46] During the renovation a year later, asbestos was found in one of the emergency stairs, which halted metro operations at the station for an additional two months.

An internal review of the renovation found that the quality of repairs fell short of standards and that these had to be redone regularly before being fully completed.

[47] In 2014, an exact replica of the station was built in Vught, North Brabant, to enable police, first aid, firefighting, and military personnel to train for emergency situations.

[48] The GVB started to play music through the speakers of underground metro stations in April 2017 as a test.

[50] By the early part of the decade, the UvA and HvA had already announced that they were planning to expand their respective campusses, necessitating increased capacity at Weesperplein.

The anti-graffiti coating was changed to light gray, resembling the original brutalist design of the station.

[61] Signatuur van de anonieme arbeider by Pieter Engels is three bronze beams forming the letter A.