He played a wide variety of traditional Chinese instruments, including Pipa, Guqin, Erhu, Xiao, and Jinghu.

[8] In 1933, he played the musical pieces Ambush from Ten Sides and The Moon over the River on a Spring Night in a documentary produced by Mingxing Film Company.

[11] In July 1938, Wei was invited by the Hong Kong Women's War Disaster Relief Association (Chinese: 香港妇女救济兵灾会) to participate in charity performances along with Xu Guangyi, Luo Songquan and other musicians.

[12] From 1938 to 1939, Wei traveled to the United States as part of a troupe, during which he performed a variety of instrumental solo and received the nickname "Kreisler of Pipa".

[14][15] After returning to China in late February 1940, Wei became a professor of Chinese music at Hujiang University with recommendation from Shen Zhibai.

[17] During the Cultural Revolution, Wei Zhongle was accused of and detained for being a "reactionary academic authority", partially for his complaints during the Great Chinese Famine.