The women's 53 kg competition of the weightlifting events at the 2015 Pan American Games in Toronto, Canada, was held on July 12 at the Oshawa Sports Centre.

The defending champion was Yuderquis Contreras from Dominican Republic.

Each lifter performed in both the snatch and clean and jerk lifts, with the final score being the sum of the lifter's best result in each.

8 athletes from six countries took part.

[1] The following record were established and improved upon during the competition.