Many other autobiographical shorts would appear in Weirdo by other artists, including Kominsky-Crumb, Carol Tyler, Phoebe Gloeckner, and Dori Seda.

[10] Contributor Kim Deitch believes that another inspiration for Weirdo was Bay Area cartoonist and zine publisher Bruce N. Duncan (often credited as "B. N.

Before Weirdo came along, Duncan published a zine called The Tele Times, covering "culture and street life in Berkeley.

"[2] In fact, said Deitch, he "first heard about Crumb’s plans to publish a new anthology from Duncan.... 'Crumb hadn’t told me about Weirdo, but he’d gotten in touch with Bruce and he definitely was one of the first people that he was buttonholing to be in the magazine.

New contributors to the magazine during this era included Lloyd Dangle, Julie Doucet, Dennis Eichhorn, Justin Green, Krystine Kryttre, Carol Tyler (her first published comics), Penny Van Horn, Michael Dougan, and Mark Zingarelli.

Many stories published in Weirdo from the "Twisted Sisters" era were later collected in the 1991 anthology Twisted Sisters: A Collection of Bad Girl Art — including work by Kominsky-Crumb, Carol Lay, Phoebe Gloeckner, Carel Moiseiwitsch, Van Horn, Kryttre, Doucet, Sternbergh, Seda, and Tyler.

[19] Weirdo was at the center of a legal case in 1986: the manager of a comics retailer in the Chicago area, Friendly Frank's, was arrested on charges of distributing obscenity.

[22] Weirdo's final issue, #28, released after a three-year hiatus in 1993, was an internationally themed 68-page giant[23] subtitled Verre D'eau (in French, "glass of water").

In 2019, Last Gasp published The Book of Weirdo: A Retrospective of R. Crumb's Legendary Humor Comics Anthology, by Jon B. Cooke.

The 288-page hardcover book "features the comprehensive story of the fondly-recalled magazine, along with testimonials from over 130 of the mag's contributors, plus interviews with Weirdo's three editors ... as well as publisher 'Baba Ron' Turner.

[25] New York's Society of Illustrators hosted an event commemorating the book's publication, with a panel of guests, including Art Spiegelman, Kim Deitch, John Holmstrom, Glenn Head, Mark Newgarden, Drew Friedman, and Cooke.